[Correspondence] Efficacy differentiation of sterile faecal filtrates in Clostridioides difficile infection

We congratulate Dina Kao and colleagues on their elegant and methodologically rigorous non-inferiority trial comparing lyophilised sterile faecal filtrate (LSFF) with lyophilised faecal microbiota transplantation (LFMT) in patients with recurrent Clostridioides difficile infection.1 This work represents the first adequately powered attempt to test whether live microbes are indispensable for the efficacy of microbiota-based therapy in this important indication.