[Correspondence] Aligning SPIRIT and SAGER guidelines for equity in clinical trials – Authors’ reply

We appreciate the comments raised by Shirin Heidari and colleagues about the need for better reporting of sex and gender considerations in randomised trials. We agree that these participant characteristics can have important implications for the planning, execution, analysis, and reporting of trials. We also thank Shirin Heidari and colleagues for the invitation to collaborate and agree that it would be useful to explore the development of supplements to the Sex and Gender Equity in Research (SAGER) and Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2025 reporting guidelines, particularly with regard to promoting trial representativeness across key sociodemographic variables1 and facilitating reliable secondary analysis of data.