[Comment] The dawn of immunotherapy in mismatch repair proficient colorectal cancer

“Immunotherapy—could that be an option for me, doctor?” is a question frequently asked by patients with colorectal cancer. The straightforward answer has long been: “No, it does not work.” However, mounting evidence from both fundamental and clinical research1 suggests that this answer is no longer appropriate. Over the past 15 years, immunotherapy has revolutionised oncology and its impact, amplified by landmark trials, media attention, and three Nobel Prizes, often contrasted with chemotherapy's unfavourable public opinion.