[Comment] Predicting stroke risk in women: are inflammation and atherosclerosis enough?

Stroke risk evolves across the lifespan, with distinct sex-specific differences that remain underappreciated in both research and clinical practice.1 One of these differences is the higher incidence of ischaemic stroke in women younger than 35 years compared with men of the same age, attributed to reproductive and hormonal factors such as oestrogen exposure, pregnancy complications, and, possibly, migraine with aura.2 In contrast, men's stroke risk accelerates more rapidly in midlife, whereas in older age (typically 75 years and older), the risk in women again surpasses that in men—driven by longer life expectancy and a higher prevalence of specific risk factors, such as atrial fibrillation.