Comment on Kofod et al. The Association Between Hemoglobin A 1c and Complications Among Individuals With Diabetes and Severe Chronic Kidney Disease. Diabetes Care 2025;48:1400–1409

We read with great interest the recent study by Kofod et al. (1), which examined the association between HbA1c and complications in diabetes with severe chronic kidney disease (CKD). The authors reported varying risk patterns across outcomes and identified a midrange HbA1c level associated with lower cardiovascular risk. While the study provides valuable insights, several methodological issues merit closer examination.