[Comment] Long-term sequelae in survivors of high-risk neuroblastoma: the price of success

Until 2000, neuroblastoma was one of the deadliest tumours of childhood, with probabilities of long-term survival not exceeding 30%. In the past two decades, children with high-risk neuroblastoma have shown remarkable improvements in event-free survival with a multimodal strategy based on induction chemotherapy, surgery, consolidation with single or tandem autologous stem-cell transplantation (ASCT), radiotherapy, and maintenance therapies with anti-GD2 antibodies plus cis-retinoic acid.1 Nowadays, through this approach, survival exceeds 50%, but, unfortunately, this improvement comes at the price of long-term sequelae for survivors.