[Comment] Increased extent of neurosurgical resection in IDH-mutated glioma: issues for translation to standard practice

Improved molecular classification of glioma has allowed identification of defined patient subgroups with prolonged survival outcomes and the potential for alternative management plans.1,2 Specifically for newly diagnosed patients with lower grade glioma (WHO grade 2–3) harbouring the IDH mutation, initial neurosurgical decision making can be complex due to the balance of optimising disease control and avoidance of long-term neurological morbidity. Additionally, these tumours present with varying neuroradiological appearance related to volume, morphology, and neuroanatomical site, which means interventions require individualisation based on these parameters.