[Comment] Gene-environment interactions underlying temporal trends in type 2 diabetes prevalence

The global prevalence of type 2 diabetes has risen dramatically over recent decades, fuelled primarily by the growing burden of obesity and characterised by an earlier onset and a multifaceted spectrum of risk factors.1 Since population-level genetic changes are not likely to be responsible for the rapid rise in diabetes prevalence, it is increasingly recognised that the type 2 diabetes epidemic is primarily driven by the escalating influence of a diabetogenic environment and its interaction with individual genetic susceptibility.