[Comment] Filtered hopes and full-spectrum realities

Given the time constraints in clinical care and research, few clinicians would invest time in writing a case report on a failed treatment approach. This publication bias explains why we should be inherently skeptical of surprising or counterintuitive medical results suggested by a case report or even a case series. Nevertheless, these same case reports can also be seeds of innovation, triggering exciting bedside to bench reverse translation. In 2017, Ott and colleagues published a case series in which they used processed faecal donations from healthy volunteers to treat recurrent Clostridioides difficile infections.