[Comment] Breaking bacterial communication: the future of next-generation antibiotics

Antimicrobial resistance (AMR) has emerged as a crucial global health threat. By 2050, approximately 1·91 million deaths are forecasted to be directly attributable to AMR, with an estimated 8·22 million deaths associated with AMR.1 In their Review published in The Lancet Microbe, Ho and colleagues emphasised the urgency of developing novel antibacterial agents that operate through mechanisms distinct from those of conventional antibiotics. The authors also highlighted a spectrum of emerging non-antibiotic strategies designed to mitigate the escalating threat of AMR.