[Comment] Brain amyloid on the way to dementia prevention

When the first scientific articles on dementia prevention were published, one of the authors of this Comment was barely in primary school and the other was nowhere near being conceived. Because most cases of dementia, even presenile, were then thought to be caused by circulatory problems (ie, atherosclerotic dementia), the preventive use of anticoagulants was hypothesised.1 Over the years, we have learnt that cognitive impairment develops due to one or, more frequently, several biological and environmental factors.