Coexistence of trapped and flow-transported nuclei enables fast pigeon post communication across multinucleated cell

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. SignificanceSyncytia house up to hundreds of thousands of nuclei within a single cell, often gigantic in size. For coordination of gene expression over such long distances, nuclei need to communicate. In search of a fast mechanism of communication, we …