CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3 (Adv. Sci. 48/2025)

Renal Cell Carcinoma In renal cell carcinoma, the circular RNA circPVT1 can promote tumor progression by encoding a novel peptide, cP104aa. The Research Article by Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao, and co‐workers (DOI: 10.1002/advs.202501211) identifies that circPVT1 encodes a 104‐amino acid peptide, termed cP104aa. On the cover, the central circular structure represents circPVT1, with a green peptide segment extending from it, which corresponds to the cP104aa peptide. Renal Cell Carcinoma In renal cell carcinoma, the circular RNA circPVT1 can promote tumor progression by encoding a novel peptide, cP104aa. The Research Article by Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao, and co-workers (DOI: 10.1002/advs.202501211 ) identifies that circPVT1 encodes a 104-amino acid peptide, termed cP104aa. On the cover, the central circular structure represents circPVT1, with a green peptide segment extending from it, which corresponds to the cP104aa peptide. Advanced Science, Volume 12, Issue 48, December 29, 2025.