Chlamydomonas chloroplast genes tolerate compression of the genetic code to just 51 codons

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. SignificanceWe demonstrate the use of theChlamydomonaschloroplast genome as a synthetic biology platform to test radical compression of the universal genetic code. Genome engineering was used to generate strains in which 13 of the 64 possible triplet …