Cell Contractile Force‐Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds (Adv. Sci. 48/2025)

Self‐Powering 4D Bioprinting This cover illustrates a morphogenetic tissue regeneration process driven by an internal stimulus: cell contractile forces (CCFs). Generated through cytoskeletal interactions, CCFs are transmitted to the surrounding matrix and neighboring cells, exerting contractile forces on the printed constructs. Programming shape changes via CCFs provides a cytocompatible, self‐powering strategy for 4D bioprinting, eliminating the need for external stimulation. More details can be found in the Research Article by Eben Alsberg and co‐workers (DOI: 10.1002/advs.202507288). Self-Powering 4D Bioprinting This cover illustrates a morphogenetic tissue regeneration process driven by an internal stimulus: cell contractile forces (CCFs). Generated through cytoskeletal interactions, CCFs are transmitted to the surrounding matrix and neighboring cells, exerting contractile forces on the printed constructs. Programming shape changes via CCFs provides a cytocompatible, self-powering strategy for 4D bioprinting, eliminating the need for external stimulation. More details can be found in the Research Article by Eben Alsberg and co-workers (DOI: 10.1002/advs.202507288 ). Advanced Science, Volume 12, Issue 48, December 29, 2025.