CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. SignificanceA key question in epigenetic memory is how DNA methylation is maintained and inherited within tightly packed heterochromatin. This process is crucial for genome stability, and its disruption can cause ICF syndrome, a disorder associated with …