Benzodiazepine Use in Pregnancy—Understanding Risks for Informed Decision-Making

Benzodiazepines are used in an estimated 2% of pregnancies in the US. Benzodiazepines cross the placenta and have been associated with a number of adverse pregnancy outcomes. Therefore, many clinicians advise avoiding benzodiazepines during pregnancy. However, benzodiazepines can play an important role in treatment of some conditions, including seizure disorders, neurological conditions and tremors, alcohol withdrawal, anxiety, and panic disorder. Furthermore, for patients with long-term benzodiazepine use, abrupt cessation can lead to withdrawal and seizure. Thus, in some circumstances, complete avoidance of benzodiazepines may be contraindicated. Understanding the risks of benzodiazepine use during pregnancy may help pregnant people and their clinicians weigh treatment benefits and risks, and make informed decisions about benzodiazepine use and management.