Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceSCN2Ais one of the strongest known genetic risk factors for autism spectrum disorder (ASD). Previous studies using brain slices showed that losing this gene lowers the excitability in dendrites of pyramidal cells in the cortex. However, it …