Asymmetrical recognition and processing of double-strand breaks formed during DNA replication

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. SignificanceDNA end resection is a critical early step in the repair of DNA double-strand breaks (DSB) by homologous recombination (HR). Studies using endonucleases that generate DSBs in all phases of the cell cycle have shown that end resection proceeds …