Association of Radiation Exposure With Insulin Resistance in Adipose Tissue and Serum Free Fatty Acid Levels

Many studies have reported that radiation exposure may increase the risk of type 2 diabetes ( 1 ). Insulin resistance in adipose tissue is considered an early and critical defect in impaired glucose metabolism because it increases serum free fatty acid (FFA) levels and consequently contributes to the progression of insulin resistance and β-cell dysfunction. However, whether radiation exposure induces insulin resistance in adipose tissue remains unclear. Thus, this study aimed to investigate the relationship between radiation exposure and insulin resistance in adipose tissue and serum FFA levels, along with the relationship between radiation exposure and hepatic and muscle insulin resistance, and β-cell function.