[Articles] Rethinking cholera diagnostic test performance, interpretation, and evaluation: a field-based latent-class analysis in Bangladesh

Our results provide potential mechanisms leading to the heterogeneous cholera RDT performance estimates in previous studies, including the use of culture as a reference assay. Across various patient and sampling characteristics, CholKit RDT had high performance in this cholera-endemic setting, supporting its use for cholera surveillance and control. Accounting for epidemiologic context is crucial both for individual-level clinical test interpretation, and for the future evaluation of diagnostics such as RDTs.