[Articles] Disease relapse, all-cause mortality, and adverse events associated with long-acting injectable antipsychotics versus oral antipsychotics in older people with schizophrenia in Hong Kong: a population-based within-subject analysis

In older individuals with schizophrenia, LAI antipsychotics were associated with lower risk of disease relapse and mortality, without increased risk of adverse events, than oral antipsychotics, except for elevated risk of extrapyramidal symptoms specifically related to first-generation LAI antipsychotics. Overall, LAI antipsychotics, especially second-generation medications, could be more broadly considered for long-term use among this population, particularly at an early stage of disease.