A metabolic cell death program downstream of SARM1 couples NAD+ depletion to BAX activation and APAF1 degradation

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. SignificanceLoss of the essential metabolic cofactor Nicotinamide adenine dinucleotide (NAD+) as a result of neuronal NADase SARM1 activation is a potent trigger of axonal degeneration and neuronal death, but how this signal executes cell death program …