A fasting-mimicking diet in patients with mild-to-moderate Crohn’s disease: a randomized controlled trial

Nature Medicine, Published online: 13 January 2026; doi:10.1038/s41591-025-04173-w In a randomized controlled trial that included 97 participants, 69% patients with Crohn’s disease (CD) allocated to a fasting-mimicking diet (FMD) achieved clinical response, and over 60% reached remission, outperforming the control group. The FMD also reduced markers of intestinal inflammation, suggesting this dietary intervention could serve as adjunctive treatment for CD. Nature Medicine, Published online: 13 January 2026; doi:10.1038/s41591-025-04173-w In a randomized controlled trial that included 97 participants, 69% patients with Crohn’s disease (CD) allocated to a fasting-mimicking diet (FMD) achieved clinical response, and over 60% reached remission, outperforming the control group. The FMD also reduced markers of intestinal inflammation, suggesting this dietary intervention could serve as adjunctive treatment for CD.