A cascade of structural rearrangements positions peptide release factor 2 for polypeptide hydrolysis on the ribosome

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificancePeptide release factor 2 (RF2) plays a crucial role in releasing the nascent polypeptide from the ribosome in several pathways, from the canonical termination of protein synthesis to the rescue of stalled ribosomes on aberrant messenger RNAs. …